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Hungary as a landlocked country is situated within the heart of the Danube Basin. The entire territory (93,030 km2) is found in the Basin. Rivers enter the country from the west, north and east and flow towards the south. Almost one fifth of the 9,8 million inhabitants live in the capital, Budapest - the City of Spas – which lies on the banks of the Danube. Lake Balaton in the west, the largest lake of the Danube Basin, is a recreational area for the country. Hungary became a Signatory Party to the Danube River Protection Convention (DRPC) in 1994 and joined the EU in 2004.

The Danube begins at the confluence of the Brigach and Breg Rivers in the city of Donaueschingen located in the Black Forest, Baden-Württemberg. The German Danube catchment area covers an area of about 56,200 km²; its share of the total Danube catchment area is approx. 7%. The German Danube basin is bordered by the Rhine basin to the west and the Elbe River basin to the east.

The Czech Republic is situated at the roof of Europe and its waters are drained through rivers into three different seas. The majority of the territory is drained by the Elbe and Oder to the North and Baltic Seas. The Morava River drains almost 28 % of the country to the Danube. Nearly 2.8 million inhabitants – around 3.46 % of the population in the Danube River Basin – live in this area.

With a national territory of 87,609 km2, Croatia is at the intersection of the Pannonian Plain, the Balkans and the Adriatic. The country straddles the border of two major catchment areas: the Danube Basin and the Adriatic Sea. Draining over 62% of Croatia’s mainland, the Danube Basin covers the northern and central inland section of the country and is home to 69% of the population. Croatian territory accounts for 4.4% of the entire Danube Basin.

The Secretariat of the ICPDR is located at the United Nations Office at Vienna (UNOV). A team of approximately 10 staff members support the work of the ICPDR and its expert & task groups, assist with project development and implementation, and maintains the ICPDR's 'DANUBIS' information system.

The ICPDR comprises 15 Contracting Parties who have committed themselves to implement the Danube River Protection Convention.

The final goals are to co-operate on fundamental water management issues and to take all appropriate legal, administrative and technical measures to maintain and improve the quality of the Danube River and its environment.

Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

Organic pollution has been on the rise in the Danube over the last century, as human activities have resulted in increasing loads of wastewater rich in organic matter. The most serious organic pollution problems occur in tributaries that regularly receive untreated or inadequately treated wastewater from industrial plants and municipalities. Thanks to the significant improvement of wastewater infrastructure and services in the Danube countries, the basin-wide organic emissions reduced by 60% since the mid 2000s.

Hazardous substances can remain in the environment for a very long time, and harm ecosystems and human health. Although monitoring indicates that the loads of some substances have been reduced in recent years, many problems still persist. The increasing number of these man-made substances present in the environment is a matter of concern, and calls for the application of the precautionary principle.