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North Macedonia, officially the Republic of North Macedonia, is a landlocked country in Southeast Europe. Its terrain is mostly rugged, located between the Šar Mountains and Osogovo, which frame the valley of the Vardar River. Three large lakes - Lake Ohrid, Lake Prespa, and Dojran Lake - lie on the southern borders, bisected by the frontiers with Albania and Greece. Ohrid is considered one of the world's oldest lakes and biotopes.

Kolotar, 4 October 2010. The acute toxic risk deriving from the heavy metals in the red sludge is rather low, as their concentrations are rather low. However, the chronic toxicity threat is high.

The Accident Emergency Warning System (AEWS) of the Danube River Basin is activated whenever there is a risk of transboundary water pollution, or threshold danger levels of certain hazardous substances are exceeded.

The Danube River is seeing an influx of new non-native species, stemming from the increasing interconnections with various European and global water bodies via canals and other waterways designed to facilitate navigation. It is currently believed that alien species are very likely to become even more significant in the future, as the importance of the Danube as an international waterway increases.