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The Sava River is the largest tributary in discharge and the second largest in catchment area. The International Sava River Basin Commission was established in 2005 to implement the Framework Agreement on the Sava River Basin (FAS RB.) The commission’s main goal is coordinating transboundary cooperation in the Sava River Basin.

North Macedonia, officially the Republic of North Macedonia, is a landlocked country in Southeast Europe. Its terrain is mostly rugged, located between the Šar Mountains and Osogovo, which frame the valley of the Vardar River. Three large lakes - Lake Ohrid, Lake Prespa, and Dojran Lake - lie on the southern borders, bisected by the frontiers with Albania and Greece. Ohrid is considered one of the world's oldest lakes and biotopes.