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The Secretariat of the ICPDR is located at the United Nations Office at Vienna (UNOV). A team of approximately 10 staff members support the work of the ICPDR and its expert & task groups, assist with project development and implementation, and maintains the ICPDR's 'DANUBIS' information system.

The ICPDR comprises 15 Contracting Parties who have committed themselves to implement the Danube River Protection Convention.

The final goals are to co-operate on fundamental water management issues and to take all appropriate legal, administrative and technical measures to maintain and improve the quality of the Danube River and its environment.

Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

19 countries share the Danube River Basin, which makes it the world’s most international river basin. 79 million people of different cultures and languages call the Danube Basin their home. For centuries they have been interconnected through the widely ramified water system of the Danube. All countries sharing over 2,000 km² of the Danube River Basin, as well as the European Union, are contracting parties of the ICPDR.

The International Commission for the Protection of the Danube River (ICPDR) works to ensure the sustainable and equitable use of waters in the Danube River Basin. The work of the ICPDR is based on the Danube River Protection Convention (DRPC), the major legal instrument for cooperation and transboundary water management in the Danube River Basin.

Floods are natural phenomena. They can, however, turn into disasters causing widespread damage, health problems and even deaths. This is especially the case where rivers have been cut off from their natural floodplains, are confined to man-made channels, and where houses and industrial sites have been constructed in areas that are naturally liable to flooding.

The best way to protect and manage water is by close international co-operation between all the countries within the river basin – bringing together all interests upstream and downstream. All countries of the European Union are using a river basin approach for water management since the adoption of the EU Water Framework Directive.

Water quality in the Danube has improved over the years, but there is still much work to be done to meet the region’s goals for water status. To improve the water quality, an ambitious programme of measures for the whole Danube River Basin District has been agreed under the EU WFD. To assess trends in water quality, the ICPDR oversees the TransNational Monitoring Network (TNMN). The network carefully monitors physical, chemical and biological conditions in the Danube and its tributaries, and provides in TNMN Yearbooks an annual overview of pollution levels as well as long term trends for water quality in the basin.