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The Sava is the Danube's largest tributary of the Danube in terms of discharge and the second largest in terms of catchment area. The Sava is shared by Slovenia, Croatia, Bosnia and Herzegovina, Serbia and Montenegro. The joint management arrangements acted as a pilot for the implementation of the European Union's Water Framework Directive for the Danube and Europe.

Covering an area of 157,186 km², the Tisza River Basin is the largest sub-basin of the Danube River Basin. The Tisza River is the longest tributary of the Danube (966 km), and second largest in terms of flow after the Sava. The countries of the Tisza Basin (Ukraine, Romania, Hungary, Slovakia, Serbia) agreed to close transboundary co-operation, aiming to achieve integrated water resources management of the Basin.

The Drava River is the fourth largest, as well as the fourth longest Danube tributary. It connects the Alps with the Danube and the Black Sea. The Drava has been considerably regulated with dams constructed to generate hydroelectricity and channels dredged to direct its flow. Nevertheless, natural habitats along the middle and lower reaches host unique varieties of flora and fauna, and several endemic species.

The International Commission for the Protection of the Danube River (ICPDR) works to ensure the sustainable and equitable use of waters in the Danube River Basin. The work of the ICPDR is based on the Danube River Protection Convention (DRPC), the major legal instrument for cooperation and transboundary water management in the Danube River Basin.

The status of waters of the Danube River Basin is largely influenced by inputs of pollutants, particularly organic material, nutrients, hazardous substances and plastics. The ICPDR regularly updates specific emission inventories addressing both point source and diffuse emissions. The ICPDR also develops policy guidance documents providing recommendations for Danube countries on how to address pollution problems and the measures that need to be implemented in order to reduce emissions. In addition, the ICPDR supports capacity building activities on issues related to pollution control.

The Danube and its tributaries host a variety of fascinating and diverse ecological territories with many unique plants and animals. The rich and unique biodiversity and riverine habitats have been under severe pressure due to human activities for centuries. However, today the protection of environment and biodiversity is on the political agenda of the different Danubian States.

The best way to protect and manage water is by close international co-operation between all the countries within the river basin – bringing together all interests upstream and downstream. All countries of the European Union are using a river basin approach for water management since the adoption of the EU Water Framework Directive.

Many people consider droughts to be rare, but in fact they are a normal and recurrent feature of the climate. Drought events are regional phenomena, affecting transnational water management. Unfortunately, droughts have a high damage potential: economic losses, ecological damages, and implications on human health.

Historically, the Danube and some of its tributaries have formed important trade routes across Europe. The harnessing of these rivers to facilitate navigation has radically changed their physical and ecological characteristics, while pollution from ships and boats is also a significant problem. In order to address this problem, the ICPDR is undertaking various activities.

Agriculture has long been a major source of income for many people living in the Danube River Basin. Today however, it is also a major source of pollutants – including fertilizers and pesticides and facing emerging issues like water scarcity and droughts.