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Evidence on plastic pollution has already been gathered in both the freshwater systems and the marine environment (including the Danube and the Black Sea) over the last decades. Scientific investigations identified strong linkages between marine pollution, terrestrial areas and land-based activities. Poor waste management, everyday littering, plastic industry facilities, consuming of products of textile and cosmetic industries in households and tire abrasion pollute rivers that further discharge plastic litter into the receiving seas. While priority should be given to reducing plastic pollution at source, river clean-up actions are also highly important to eliminate plastic litter accumulation hot-spots.

Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".