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The ICPDR serves as a conduit for collaboration between Danube countries and the Black Sea region in matters necessitating coordinated action. It also collaborates with other international organizations in other river basins to tackle emerging challenges linked to water management (e.g., climate change adaptation). Partnerships with relevant international organizations to effectively address emerging challenges associated with water management, such as climate change adaptation are also part of the ICPDR's coopertaion activities.

Organic pollution has been on the rise in the Danube over the last century, as human activities have resulted in increasing loads of wastewater rich in organic matter. The most serious organic pollution problems occur in tributaries that regularly receive untreated or inadequately treated wastewater from industrial plants and municipalities. Thanks to the significant improvement of wastewater infrastructure and services in the Danube countries, the basin-wide organic emissions reduced by 60% since the mid 2000s.