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The Secretariat of the ICPDR is located at the United Nations Office at Vienna (UNOV). A team of approximately 10 staff members support the work of the ICPDR and its expert & task groups, assist with project development and implementation, and maintains the ICPDR's 'DANUBIS' information system.

Hazardous substances can remain in the environment for a very long time, and harm ecosystems and human health. Although monitoring indicates that the loads of some substances have been reduced in recent years, many problems still persist. The increasing number of these man-made substances present in the environment is a matter of concern, and calls for the application of the precautionary principle.