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Moldova is one of the smaller countries of the Danube River Basin, but the Danube touches the southern point of Moldova for about 340 meters. Picturesque Moldova holds over 12,500km² of the Danube River Basin, including 8,300km² of the Prut River Sub-Basin, 3,300km² of the Yalpugh River Sub-Basin and 900km² of the Cahul River Sub-Basin.

As both the largest remaining natural wetland and second largest river delta in Europe, the Danube Delta is one of the continent's most valuable habitats for wetland wildlife. Pollution and discharge manipulation from upstream has a huge effect on this area of high biodiversity, plus the delta continues to change ecologically itself – the Danube Delta spreads seaward at a rate of 10 to 25 metres every year.

The International Commission for the Protection of the Danube River (ICPDR) works to ensure the sustainable and equitable use of waters in the Danube River Basin. The work of the ICPDR is based on the Danube River Protection Convention (DRPC), the major legal instrument for cooperation and transboundary water management in the Danube River Basin.